9. Pediatric Dosage in Children (Birth to 15 Years)

View in chapter → Standard Therapy for Current (Active) TB Disease

Last Updated April 2026

Principle: Initiation of therapy for active TB disease requires a multi-drug regimen, typically including Isoniazid, Rifampin, Pyrazinamide, and Ethambutol (for suspected or proven drug-susceptible TB disease).
Child's Weight (lbs) Child's Weight (kg) Daily Dose (mg) 10-15 mg/kg PO
6 - 10 3 - 4.5 50
11 - 14 5.0 - 6.0 50
14.5 - 18 6.5 – 8.0 100
18.5 - 21.5 8.5 – 9.5 100
22 – 24 10.0 – 11 150
25 - 29 11.5 - 13 150
29.5 - 32 13.5 - 14.5 200
33 - 35 15 - 16 200
36 - 40 16.5 - 18 250
40.5 - 43 18.5 - 19.5 250
44 - 48 20 - 21.5 300
48.5 - 51 22 - 23 300
52 - 54.5 23.5 - 24.5 300
55 - 57.5 25 - 26 300
58 - 62 26.5 - 28 300
62.5 - 65 28.5 - 29.5 300
66 + 30 + 300

NOTE: Isoniazid tablets come in 50 mg, 100mg, 300 mg sizes and can be crushed for oral administration. Isoniazid tablets are also scored.

Isoniazid Syrup (50mg/5ml) should not be refrigerated. It contains sorbitol and will cause diarrhea. It should be used only when crushed tablets cannot accommodate the situation. (keep at room temperature).

Principle: Initiation of therapy for active TB disease requires a multi-drug regimen, typically including Isoniazid, Rifampin, Pyrazinamide, and Ethambutol (for suspected or proven drug-susceptible TB disease).
Child's Weight (lbs) Child's Weight (kg) Daily Dose (mg) 10-20 mg/kg
15 - 32 7 - 14.5 150 mg
33 - 48.5 15 - 22 300 mg
49 - 65 22.5 - 29.5 450 mg
66 + 30 + 600 mg
Principle: Initiation of therapy for active TB disease requires a multi-drug regimen, typically including Isoniazid, Rifampin, Pyrazinamide, and Ethambutol (for suspected or proven drug-susceptible TB disease).
Child’s Weight (lbs) Child’s Weight (kg) Daily Dose (mg) 15 – 25 mg/kg
11 – 15 5 – 7 100 mg
16 – 31 8 – 14 200 mg
32 – 44 15 – 20 300 mg
45 – 55 21 – 25 400 mg
56 – 67 26 – 30.5 500 mg
68 – 76 31 – 34.5 600 mg
77 – 87 35 – 39.5 700 mg
88 – 121 40 – 55 800 mg
122 – 165 56 – 75 1200 mg
166 + 76 + 1600 mg

Additional Notes:
The maximum recommendation for ethambutol is 1g daily.

Principle: Initiation of therapy for active TB disease requires a multi-drug regimen, typically including Isoniazid, Rifampin, Pyrazinamide, and Ethambutol (for suspected or proven drug-susceptible TB disease).
Child's Weight (lbs) Child's Weight (kg) Daily Dose (mg) 30-40 mg/kg
13 - 23 6 - 10.5 250 mg
24 - 26 11 - 12 250 mg
27 - 31 12.5 - 14 500 mg
32 - 41 14.5 - 18.5 500 mg
42 - 47 19.0 - 21.5 750 mg
48 - 54 22.0 - 24.5 750 mg
55 – 63 25 – 28.5 1000 mg
64 – 67 29 – 30.5 1000 mg
68 – 80 31 – 36.5 1250 mg
81 – 93 37 – 42.5 1500 mg
94 – 106 43 – 48.5 1750 mg
107 + 49 + 2000 mg