GA TB Reference Guide

Duration	3 months
Dosage And Age Group	Adults and children aged ≥ 12 yrs Isoniazid i: 15 mg/kg rounded up to the nearest 50 or 100 mg; 900 mg maximum Rifapentine i: 10 - 14.0 kg, 300 mg 14.1 - 25.0 kg, 450 mg 25. 1 - 32.0 kg, 600 mg 32.1 - 49.9 kg, 750 mg > 50.0 kg, 900 mg maximum Children aged 2 - 11 yrs Isoniazid i: 25 mg/kg; 900 mg maximum Rifapentine i: see above
Frequency	Once weekly
Total doses	12

Duration	4 months
Dosage And Age Group	Adults 10 mg/kg Children 15 - 20 mg/kg i Maximum dose 600 mg
Frequency	Daily
Total doses	120

Duration	3 months
Dosage And Age Group	Adults Isoniazid i: 5 mg/kg; 300 mg maximum Rifampin i: 10 mg/kg; 600 mg maximum Children: Isoniazid i: 10 - 20 mg/kg i ; 300 mg maximum Rifampin i: 15 - 20 mg/kg; 600 mg maximum
Frequency	Daily
Total doses	90

Duration	9 months	6 months
Dosage And Age Group	Adults 5 mg/kg Children 10 - 20 mg/kg i Maximum dose 300 mg	Adults 5 mg/kg Children 10 - 20 mg/kg i Maximum dose 300 mg
Frequency	Daily	Daily
Total doses	270	180

1. Isoniazid is formulated as 100-mg and 300-mg tablets.
2. Rifapentine is formulated as 150-mg tablets in blister packs that should be kept sealed until use. Rifapentine should not be used for children <2 years of age due to lack of pharmacokinetic data.
3. Rifampin (rifampicin) is formulated as 150-mg and 300-mg capsules.