II. Diagnostic Tests for Latent TB Infection (LTBI)

Last Updated April 2026

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Anergy testing is not recommended for routine use in persons living with HIV or otherwise immunocompromised. Factors limiting the usefulness of anergy skin testing include problems with the standardization and reproducibility, the low risk for TB disease associated with a diagnosis of anergy, and the lack of apparent benefit of treatment of LTBI for groups of anergic persons living with HIV in the U.S.